TrkA Gene Ablation in Basal Forebrain Results in Dysfunction of the Cholinergic Circuitry

Dysfunction of basal forebrain cholinergic neurons (BFCNs) is an early pathological hallmark of Alzheimer's disease (AD). Numerous studies have indicated that nerve growth factor (NGF) supports survival and phenotypic differentiation of BFCNs. Consistent with a potential link to AD pathogenesis...

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Main Authors: Sanchez-Ortiz, Efrain, Yui, Daishi, Song, Dongli, Li, Yun, Rubenstein, John L., Reichardt, Louis F., Parada, Luis F.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2012
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403817/
https://ncbi.nlm.nih.gov/pubmed/22442072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6314-11.2012
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