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On the unyielding hydrophobic core of villin headpiece

Villin headpiece (HP67) is a small, autonomously-folding domain that has become a model system for understanding the fundamental tenets governing protein folding. In this communication, we explore the role that Leu61 plays in the structure and stability of the construct. Deletion of Leu61 results in...

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Bibliographic Details
Main Authors: Brown, Jeffrey W, Farelli, Jeremiah D, McKnight, C James
Format: Artigo
Language:Inglês
Published: Wiley Subscription Services, Inc., A Wiley Company 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403462/
https://ncbi.nlm.nih.gov/pubmed/22467489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2048
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