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Probing the catalytic mechanism of a C-3′-methyltransferase involved in the biosynthesis of d-tetronitrose

d-Tetronitrose is a nitro-containing tetradeoxysugar found attached to the antitumor and antibacterial agent tetrocarcin A. The biosynthesis of this highly unusual sugar in Micromonospora chalcea requires 10 enzymes. The fifth step in the pathway involves the transfer of a methyl group from S-adenos...

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Detalhes bibliográficos
Main Authors: Bruender, Nathan A, Holden, Hazel M
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403422/
https://ncbi.nlm.nih.gov/pubmed/22495991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2074
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