Steric recognition of T-cell receptor contact residues is required to map mutant epitopes by immunoinformatical programmes

MHC class I-restricted CD8 T-lymphocyte epitopes comprise anchor motifs, T-cell receptor (TCR) contact residues and the peptide backbone. Serial variant epitopes with substitution of amino acids at either anchor motifs or TCR contact residues have been synthesized for specific interferon-γ responses...

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Main Authors: Hsu, Shiou-Chih, Chang, Chih-Peng, Tsai, Chao-Yuan, Hsieh, Shih-Hung, Wu-Hsieh, Betty A, Lo, Yu-Shu, Yang, Jinn-Moon
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2012
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403262/
https://ncbi.nlm.nih.gov/pubmed/22121944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2011.03542.x
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