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Effects of ketoconazole and valproic acid on the pharmacokinetics of the next generation NNRTI, lersivirine (UK-453,061), in healthy adult subjects

AIMS: To investigate the effect of inhibitors of cytochrome P450 (CYP) 3A4 and glucuronidation (UGT2B7) on the pharmacokinetics of lersivirine (UK-453,061), a next generation non-nucleoside reverse transcriptase inhibitor with a unique resistance profile, and to investigate the safety and tolerabili...

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Autori principali: Langdon, Grant, Davis, John, Layton, Gary, Chong, Chew-Lan, Weissgerber, Georges, Vourvahis, Manoli
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403204/
https://ncbi.nlm.nih.gov/pubmed/22040521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.04136.x
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