Inhibition of the organic anion-transporting polypeptide 1B1 by quercetin: an in vitro and in vivo assessment

AIM: To investigate the effect of quercetin on organic anion transporting polypeptide 1B1 (OATP1B1) activities in vitro and on the pharmacokinetics of pravastatin, a typical substrate for OATP1B1 in healthy Chinese-Han male subjects. METHODS: Using human embryonic kidney 293 (HEK293) cells stably ex...

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Detalhes bibliográficos
Main Authors: Wu, Lan-Xiang, Guo, Cheng-Xian, Chen, Wang-Qing, Yu, Jing, Qu, Qiang, Chen, Yao, Tan, Zhi-Rong, Wang, Guo, Fan, Lan, Li, Qing, Zhang, Wei, Zhou, Hong-Hao
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403202/
https://ncbi.nlm.nih.gov/pubmed/22114872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.04150.x
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