Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP

BACKGROUND AND PURPOSE: An ATP-binding cassette (ABC) transporter, breast cancer resistance protein (BCRP)/ABCG2, limits oral bioavailability of sulphasalazine. Here we examined the effect of curcumin, the principal curcuminoid of turmeric, on oral bioavailability of microdoses and therapeutic doses...

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Main Authors: Kusuhara, Hiroyuki, Furuie, Hidetoshi, Inano, Akihiro, Sunagawa, Akihiro, Yamada, Saiko, Wu, Chunyong, Fukizawa, Shinya, Morimoto, Nozomi, Ieiri, Ichiro, Morishita, Mariko, Sumita, Kiminobu, Mayahara, Hiroshi, Fujita, Takuya, Maeda, Kazuya, Sugiyama, Yuichi
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 2012
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402804/
https://ncbi.nlm.nih.gov/pubmed/22300367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01887.x
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