Inhibition of ROS-induced apoptosis in endothelial cells by nitrone spin traps via induction of phase II enzymes and suppression of mitochondria-dependent pro-apoptotic signaling

Oxidative stress is the main etiological factor behind the pathogenesis of various diseases including inflammation, cancer, cardiovascular and neurodegenerative disorders. Due to the spin trapping abilities and various pharmacological properties of nitrones, their application as therapeutic agent ha...

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Autores principales: Das, Amlan, Gopalakrishnan, Bhavani, Voss, Oliver H., Doseff, Andrea I., Villamena, Frederick A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402614/
https://ncbi.nlm.nih.gov/pubmed/22580046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.04.021
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