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(Pro)renin Receptor Triggers Distinct Angiotensin II-Independent Extracellular Matrix Remodeling and Deterioration of Cardiac Function

BACKGROUND: Activation of the renin-angiotensin-system (RAS) plays a key pathophysiological role in heart failure in patients with hypertension and myocardial infarction. However, the function of (pro)renin receptor ((P)RR) is not yet solved. We determined here the direct functional and structural e...

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Detalhes bibliográficos
Main Authors: Moilanen, Anne-Mari, Rysä, Jaana, Serpi, Raisa, Mustonen, Erja, Szabò, Zoltán, Aro, Jani, Näpänkangas, Juha, Tenhunen, Olli, Sutinen, Meeri, Salo, Tuula, Ruskoaho, Heikki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402428/
https://ncbi.nlm.nih.gov/pubmed/22911790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041404
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