Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment()

Human mesenchymal stem cells (hMSCs) are bone marrow-derived stromal cells, which play a role in tumor progression. We have shown earlier that breast cancer cells secrete higher levels of interleukin-6 (IL-6) under hypoxia, leading to the recruitment of hMSCs towards hypoxic tumor cells. We found th...

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Hlavní autoři: Rattigan, Yanique I., Patel, Brijesh B., Ackerstaff, Ellen, Sukenick, George, Koutcher, Jason A., Glod, John W., Banerjee, Debabrata
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402174/
https://ncbi.nlm.nih.gov/pubmed/22178238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2011.11.014
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