Functional polymorphisms in CYP2C19 & CYP3A5 genes associated with decreased susceptibility for paediatric tuberculosis

BACKGROUND & OBJECTIVES: Tuberculosis (TB) bacilli ingested by macrophages evade host immune responses by multiple mechanisms including the inhibition of apoptosis. As the cytochrome-P-450 system (CYP) contributes to apoptosis it has been suggested that genetic variation in CYP may be associated...

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Autors principals: Feng, Wei-Xing, Liu, Fang, Gu, Yi, Jiao, Wei-Wei, Sun, Lin, Xiao, Jing, Wu, Xi-Rong, Miao, Qing, Shen, Chen, Shen, Dan, Shen, Adong
Format: Artigo
Idioma:Inglês
Publicat: Medknow Publications & Media Pvt Ltd 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401694/
https://ncbi.nlm.nih.gov/pubmed/22771593
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