Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding

The crucial role of Myc as an oncoprotein and as a key regulator of cell growth makes it essential to understand the molecular basis of Myc function. The N-terminal region of c-Myc coordinates a wealth of protein interactions involved in transformation, differentiation and apoptosis. We have charact...

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Bibliographische Detailangaben
Hauptverfasser: Andresen, Cecilia, Helander, Sara, Lemak, Alexander, Farès, Christophe, Csizmok, Veronika, Carlsson, Jonas, Penn, Linda Z., Forman-Kay, Julie D., Arrowsmith, Cheryl H., Lundström, Patrik, Sunnerhagen, Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2012
Schlagworte:
Structural Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401448/
https://ncbi.nlm.nih.gov/pubmed/22457068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks263
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