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Lack of Thrombospondin-2 Reduces Fibrosis and Increases Vascularity Around Cardiac Cell Grafts

BACKGROUND: Fibrosis around cardiac cell injections represents an obstacle to graft integration in cell-based cardiac repair. Thrombospondin-2 (TSP-2) is a pro-fibrotic, anti-angiogenic matricellular protein and an attractive target for therapeutic knockdown to improve cardiac graft integration and...

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Detalhes bibliográficos
Main Authors: Reinecke, Hans, Robey, Thomas E., Mignone, John, Muskheli, Veronica, Bornstein, Paul, Murry, Charles E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401337/
https://ncbi.nlm.nih.gov/pubmed/22512900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.carpath.2012.03.005
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