The kunitz protease inhibitor domain of protease nexin-2 inhibits factor XIa and murine carotid artery and middle cerebral artery thrombosis

Coagulation factor XI (FXI) plays an important part in both venous and arterial thrombosis, rendering FXIa a potential target for the development of antithrombotic therapy. The kunitz protease inhibitor (KPI) domain of protease nexin-2 (PN2) is a potent, highly specific inhibitor of FXIa, suggesting...

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Detalhes bibliográficos
Main Authors: Wu, Wenman, Li, Hongbo, Navaneetham, Duraiswamy, Reichenbach, Zachary W., Tuma, Ronald F., Walsh, Peter N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401218/
https://ncbi.nlm.nih.gov/pubmed/22674803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-419523
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