Antigen Binding Characteristics of Immunoglobulin Free Light Chains: Crosslinking by Antigen is Essential to Induce Allergic Inflammation

Beside the production of complete immunoglobulins IgG, IgE, IgA, IgM and IgD, consisting of tetrameric heterodimers of immunoglobulin heavy and light chains, B cells also secrete immunoglobulin free light chains (Ig-fLC). Previous studies showed that Ig-fLCs are able to induce immediate hypersensiti...

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Detalhes bibliográficos
Main Authors: Thio, Marco, Groot Kormelink, Tom, Fischer, Marcel J., Blokhuis, Bart R., Nijkamp, Frans P., Redegeld, Frank A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401207/
https://ncbi.nlm.nih.gov/pubmed/22911727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040986
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