Targeted Silencing of Elongation Factor 2 Kinase Suppresses Growth and Sensitizes Tumors to Doxorubicin in an Orthotopic Model of Breast Cancer

Eukaryotic elongation factor 2 kinase (eEF-2K), through its phosphorylation of elongation factor 2 (eEF2), provides a mechanism by which cells can control the rate of the elongation phase of protein synthesis. The activity of eEF-2K is increased in rapidly proliferating malignant cells, is inhibited...

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Detalhes bibliográficos
Main Authors: Tekedereli, Ibrahim, Alpay, S. Neslihan, Tavares, Clint D. J., Cobanoglu, Zehra E., Kaoud, Tamer S., Sahin, Ibrahim, Sood, Anil K., Lopez-Berestein, Gabriel, Dalby, Kevin N., Ozpolat, Bulent
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401164/
https://ncbi.nlm.nih.gov/pubmed/22911754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041171
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