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Vancomycin-Modified Implant Surface Inhibits Biofilm Formation and Supports Bone-Healing in an Infected Osteotomy Model in Sheep: A Proof-of-Concept Study

BACKGROUND: Implant-associated infections contribute to patient morbidity and health care costs. We hypothesized that surface modification of titanium fracture hardware with vancomycin would support bone-healing and prevent bacterial colonization of the implant in a large-animal model. METHODS: A un...

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Main Authors: Stewart, Suzanne, Barr, Stephanie, Engiles, Julie, Hickok, Noreen J., Shapiro, Irving M., Richardson, Dean W., Parvizi, Javad, Schaer, Thomas P.
פורמט: Artigo
שפה:Inglês
יצא לאור: Journal of Bone and Joint Surgery, Inc. 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401139/
https://ncbi.nlm.nih.gov/pubmed/22854994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2106/JBJS.K.00886
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