C4ST-1/CHST11-controlled chondroitin sulfation interferes with oncogenic HRAS signaling in Costello syndrome

Costello syndrome is a pediatric genetic disorder linked to oncogenic germline mutations in the HRAS gene. The disease is characterized by multiple developmental abnormalities, as well as predisposition to malignancies. Our recent observation that heart tissue from patients with Costello syndrome sh...

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Hlavní autoři: Klüppel, Michael, Samavarchi-Tehrani, Payman, Liu, Kela, Wrana, Jeffrey L, Hinek, Aleksander
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400726/
https://ncbi.nlm.nih.gov/pubmed/22317973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2012.12
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