TRIM27 Negatively Regulates NOD2 by Ubiquitination and Proteasomal Degradation

NOD2, the nucleotide-binding domain and leucine-rich repeat containing gene family (NLR) member 2 is involved in mediating antimicrobial responses. Dysfunctional NOD2 activity can lead to severe inflammatory disorders, but the regulation of NOD2 is still poorly understood. Recently, proteins of the...

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Autori principali: Zurek, Birte, Schoultz, Ida, Neerincx, Andreas, Napolitano, Luisa M., Birkner, Katharina, Bennek, Eveline, Sellge, Gernot, Lerm, Maria, Meroni, Germana, Söderholm, Johan D., Kufer, Thomas A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400628/
https://ncbi.nlm.nih.gov/pubmed/22829933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041255
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