Immunotherapeutic Targeting of Membrane Hsp70-Expressing Tumors Using Recombinant Human Granzyme B

BACKGROUND: We have previously reported that human recombinant granzyme B (grB) mediates apoptosis in membrane heat shock protein 70 (Hsp70)-positive tumor cells in a perforin-independent manner. METHODOLOGY/PRINCIPAL FINDINGS: Optical imaging of uptake kinetics revealed co-localization of grB with...

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Autori principali: Gehrmann, Mathias, Stangl, Stefan, Kirschner, Andreas, Foulds, Gemma A., Sievert, Wolfgang, Doß, Brigitte T., Walch, Axel, Pockley, Alan G., Multhoff, Gabriele
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400620/
https://ncbi.nlm.nih.gov/pubmed/22829941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041341
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