The Pore-Forming Toxin β hemolysin/cytolysin Triggers p38 MAPK-Dependent IL-10 Production in Macrophages and Inhibits Innate Immunity

Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns and immune-compromised adults. The pore-forming toxin (PFT) β hemolysin/cytolysin (βh/c) is a major virulence factor for GBS, which is generally attributed to its cytolytic functions. Here we show βh/c...

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Detalhes bibliográficos
Main Authors: Bebien, Magali, Hensler, Mary E., Davanture, Suzel, Hsu, Li-Chung, Karin, Michael, Park, Jin Mo, Alexopoulou, Lena, Liu, George Y., Nizet, Victor, Lawrence, Toby
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400567/
https://ncbi.nlm.nih.gov/pubmed/22829768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002812
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