A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breas...

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Main Authors: Coviello, Andrea D., Haring, Robin, Wellons, Melissa, Vaidya, Dhananjay, Lehtimäki, Terho, Keildson, Sarah, Lunetta, Kathryn L., He, Chunyan, Fornage, Myriam, Lagou, Vasiliki, Mangino, Massimo, Onland-Moret, N. Charlotte, Chen, Brian, Eriksson, Joel, Garcia, Melissa, Liu, Yong Mei, Koster, Annemarie, Lohman, Kurt, Lyytikäinen, Leo-Pekka, Petersen, Ann-Kristin, Prescott, Jennifer, Stolk, Lisette, Vandenput, Liesbeth, Wood, Andrew R., Zhuang, Wei Vivian, Ruokonen, Aimo, Hartikainen, Anna-Liisa, Pouta, Anneli, Bandinelli, Stefania, Biffar, Reiner, Brabant, Georg, Cox, David G., Chen, Yuhui, Cummings, Steven, Ferrucci, Luigi, Gunter, Marc J., Hankinson, Susan E., Martikainen, Hannu, Hofman, Albert, Homuth, Georg, Illig, Thomas, Jansson, John-Olov, Johnson, Andrew D., Karasik, David, Karlsson, Magnus, Kettunen, Johannes, Kiel, Douglas P., Kraft, Peter, Liu, Jingmin, Ljunggren, Östen, Lorentzon, Mattias, Maggio, Marcello, Markus, Marcello R. P., Mellström, Dan, Miljkovic, Iva, Mirel, Daniel, Nelson, Sarah, Morin Papunen, Laure, Peeters, Petra H. M., Prokopenko, Inga, Raffel, Leslie, Reincke, Martin, Reiner, Alex P., Rexrode, Kathryn, Rivadeneira, Fernando, Schwartz, Stephen M., Siscovick, David, Soranzo, Nicole, Stöckl, Doris, Tworoger, Shelley, Uitterlinden, André G., van Gils, Carla H., Vasan, Ramachandran S., Wichmann, H.-Erich, Zhai, Guangju, Bhasin, Shalender, Bidlingmaier, Martin, Chanock, Stephen J., De Vivo, Immaculata, Harris, Tamara B., Hunter, David J., Kähönen, Mika, Liu, Simin, Ouyang, Pamela, Spector, Tim D., van der Schouw, Yvonne T., Viikari, Jorma, Wallaschofski, Henri, McCarthy, Mark I., Frayling, Timothy M., Murray, Anna, Franks, Steve, Järvelin, Marjo-Riitta, de Jong, Frank H., Raitakari, Olli, Teumer, Alexander, Ohlsson, Claes, Murabito, Joanne M., Perry, John R. B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400553/
https://ncbi.nlm.nih.gov/pubmed/22829776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002805
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