The imbalance between Treg and Th17 cells caused by FTY720 treatment in skin allograft rejection

OBJECTIVES: FTY720 modulates CD4(+)T cells by the augmentation of regulatory T cell activity, secretion of suppressive cytokines and suppression of IL-17 secretion by Th17 cells. To further understand the process of graft rejection/acceptance, we evaluated skin allograft survival and associated even...

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Main Authors: Commodaro, Alessandra Gonçalves, Pedregosa, Juliana Figueredo, Peron, Jean Pierre, Brandão, Wesley, Rizzo, Luiz Vicente, Bueno, Valquiria
Format: Artigo
Jezik:Inglês
Izdano: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2012
Teme:
Basic Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400173/
https://ncbi.nlm.nih.gov/pubmed/22892927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.6061/clinics/2012(07)17
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