Modeling and Experimental Analyses Reveals Signaling Plasticity in a Bi-Modular Assembly of CD40 Receptor Activated Kinases

Depending on the strength of signal dose, CD40 receptor (CD40) controls ERK-1/2 and p38MAPK activation. At low signal dose, ERK-1/2 is maximally phosphorylated but p38MAPK is minimally phosphorylated; as the signal dose increases, ERK-1/2 phosphorylation is reduced whereas p38MAPK phosphorylation is...

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Detalhes bibliográficos
Main Authors: Sarma, Uddipan, Sareen, Archana, Maiti, Moitrayee, Kamat, Vanita, Sudan, Raki, Pahari, Sushmita, Srivastava, Neetu, Roy, Somenath, Sinha, Sitabhra, Ghosh, Indira, Chande, Ajit G., Mukhopadhyaya, Robin, Saha, Bhaskar
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399835/
https://ncbi.nlm.nih.gov/pubmed/22815717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039898
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