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Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods
The pharmacological suppression of the DNA damage response and DNA repair can increase the therapeutic indices of conventional chemotherapeutics. Replication Protein A (RPA), the major single-stranded DNA binding protein in eukaryotes, is required for DNA replication, DNA repair, DNA recombination,...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3399738/ https://ncbi.nlm.nih.gov/pubmed/21459001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.03.012 |
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