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An overview of the development of combined oral contraceptives containing estradiol: focus on estradiol valerate/dienogest

Natural estrogens such as estradiol (E(2)) or its valerate ester (E(2)V) offer an alternative to ethinyl estradiol (EE). E(2)-containing combined oral contraceptives (COCs) have demonstrated sufficient ovulation inhibition and acceptable contraceptive efficacy. However, earlier formulations were gen...

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Hlavní autoři: Fruzzetti, Franca, Trémollieres, Florence, Bitzer, Johannes
Médium: Artigo
Jazyk:Inglês
Vydáno: Informa Healthcare 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399636/
https://ncbi.nlm.nih.gov/pubmed/22468839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/09513590.2012.662547
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