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Rates of brain atrophy and clinical decline over 6 and 12-month intervals in PSP: determining sample size for treatment trials

Imaging biomarkers are useful outcome measures in treatment trials. We compared sample size estimates for future treatment trials performed over 6 or 12-months in progressive supranuclear palsy using both imaging and clinical measures. We recruited 16 probable progressive supranuclear palsy patients...

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Detalhes bibliográficos
Main Authors: Whitwell, Jennifer L., Xu, Jia, Mandrekar, Jay, Gunter, Jeffrey L., Jack, Clifford R., Josephs, Keith A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399183/
https://ncbi.nlm.nih.gov/pubmed/22079523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.parkreldis.2011.10.013
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