Design of the Novel Protraction Mechanism of Insulin Degludec, an Ultra-long-Acting Basal Insulin

PURPOSE: Basal insulins with improved kinetic properties can potentially be produced using acylation by fatty acids that enable soluble, high-molecular weight complexes to form post-injection. A series of insulins, acylated at B29 with fatty acids via glutamic acid spacers, were examined to deduce t...

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Bibliographic Details
Main Authors: Jonassen, Ib, Havelund, Svend, Hoeg-Jensen, Thomas, Steensgaard, Dorte Bjerre, Wahlund, Per-Olof, Ribel, Ulla
Format: Artigo
Language:Inglês
Published: Springer US 2012
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399081/
https://ncbi.nlm.nih.gov/pubmed/22485010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-012-0739-z
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