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Detectable minimal residual disease before hematopoietic cell transplantation is prognostic but does not preclude cure for children with very-high-risk leukemia

In patients with acute leukemia, detection of minimal residual disease (MRD) before allogeneic hematopoietic cell transplantation (HCT) correlates with risk of relapse. However, the level of MRD that is most likely to preclude cure by HCT is unclear, and the benefit of further chemotherapy to reduce...

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Detalhes bibliográficos
Main Authors: Leung, Wing, Pui, Ching-Hon, Coustan-Smith, Elaine, Yang, Jie, Pei, Deqing, Gan, Kwan, Srinivasan, Ashok, Hartford, Christine, Triplett, Brandon M., Dallas, Mari, Pillai, Asha, Shook, David, Rubnitz, Jeffrey E., Sandlund, John T., Jeha, Sima, Inaba, Hiroto, Ribeiro, Raul C., Handgretinger, Rupert, Laver, Joseph H., Campana, Dario
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398757/
https://ncbi.nlm.nih.gov/pubmed/22517895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-02-409813
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