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Quiescent keratocytes fail to repair MMC induced DNA damage leading to the long-term inhibition of myofibroblast differentiation and wound healing

PURPOSE: The purpose of this study was to determine the acute and long-term effects of mitomycin C (MMC) on quiescent rabbit corneal keratocytes regarding cell proliferation, myofibroblast differentiation and DNA repair. METHODS: Quiescent keratocytes cultured in serum-free media were exposed to var...

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Detalhes bibliográficos
Main Authors: Jester, James V., Nien, Chyong Jy, Vasiliou, Vasilis, Brown, Donald J.
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Vision 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398499/
https://ncbi.nlm.nih.gov/pubmed/22815636
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