Critical Analysis of Treatment Trials of Rhesus Macaques Infected with Borrelia burgdorferi Reveals Important Flaws in Experimental Design

A critical analysis of two treatment trials of Chinese rhesus macaques infected with Borrelia burgdorferi indicates that insufficient attention was placed on documenting the blood levels, pharmacokinetics, and pharmacodynamic parameters of the antibiotics used in this host. Consequently, it is impos...

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Bibliographische Detailangaben
Hauptverfasser: Wormser, Gary P., Baker, Phillip J., O'Connell, Susan, Pachner, Andrew R., Schwartz, Ira, Shapiro, Eugene D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2012
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398392/
https://ncbi.nlm.nih.gov/pubmed/22620495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/vbz.2012.1012
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