Anti-inflammatory/anti-fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against Schistosoma mansoni-induced liver fibrosis

BACKGROUND: Praziquantel (PZQ) is an isoquinoline derivative (2-cyclohexylcarbonyl-1, 2, 3, 6, 7, 11b-hexahydro-4H-pyrazino{2,1-a}-isoquinoline-4-one), and is currently the drug of choice for all forms of schistosomiasis. Silymarin, a standardized milk thistle extract, of which silibinin is the main...

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Autores principales: El-Lakkany, Naglaa M, Hammam, Olfat A, El-Maadawy, Walaa H, Badawy, Afkar A, Ain-Shoka, Afaf A, Ebeid, Fatma A
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398291/
https://ncbi.nlm.nih.gov/pubmed/22236605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-3305-5-9
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