Continuous estrone treatment impairs spatial memory and does not impact number of basal forebrain cholinergic neurons in the surgically menopausal middle-aged rat

Premarin (conjugated equine estrogens) is the most widely prescribed estrogen-only menopausal hormone therapy in the United States, and is comprised of over 50% estrone (E1) sulfate. Following CEE administration, E1 is the principal circulating estrogen. However, the cognitive and neurobiological ef...

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Autors principals: Engler-Chiurazzi, Elizabeth B., Talboom, Joshua S., Braden, B. Blair, Tsang, Candy W.S., Mennenga, Sarah, Andrews, Madeline, Demers, Laurence M., Bimonte-Nelson, Heather A.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397199/
https://ncbi.nlm.nih.gov/pubmed/22522079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yhbeh.2012.04.004
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