Involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor

P2X receptors (P2XRs) are ligand-gated ion channels activated by extracellular ATP. Although the crystal structure of the zebrafish P2X4R has been solved, the exact mode of ATP binding and the conformational changes governing channel opening and desensitization remain unknown. Here, we used voltage...

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Detalhes bibliográficos
Main Authors: Lörinczi, Éva, Bhargava, Yogesh, Marino, Stephen F., Taly, Antoine, Kaczmarek-Hájek, Karina, Barrantes-Freer, Alonso, Dutertre, Sébastien, Grutter, Thomas, Rettinger, Jürgen, Nicke, Annette
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396496/
https://ncbi.nlm.nih.gov/pubmed/22745172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118759109
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