Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy

Hypomagnesemia affects insulin resistance and is a risk factor for diabetes mellitus type 2 (DM2) and gestational diabetes mellitus (GDM). Two single nucleotide polymorphisms (SNPs) in the epithelial magnesium channel TRPM6 (V(1393)I, K(1584)E) were predicted to confer susceptibility for DM2. Here,...

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Detalhes bibliográficos
Main Authors: Nair, Anil V., Hocher, Berthold, Verkaart, Sjoerd, van Zeeland, Femke, Pfab, Thiemo, Slowinski, Torsten, Chen, You-Peng, Schlingmann, Karl Peter, Schaller, André, Gallati, Sabina, Bindels, René J., Konrad, Martin, Hoenderop, Joost G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396482/
https://ncbi.nlm.nih.gov/pubmed/22733750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113811109
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