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Induction of hepatocellular carcinoma by in vivo gene targeting
The distinct phenotypic and prognostic subclasses of human hepatocellular carcinoma (HCC) are difficult to reproduce in animal experiments. Here we have used in vivo gene targeting to insert an enhancer-promoter element at an imprinted chromosome 12 locus in mice, thereby converting ∼1 in 20,000 nor...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3396480/ https://ncbi.nlm.nih.gov/pubmed/22733778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117032109 |
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