MUC1 carrying core 2 O-glycans functions as a molecular shield against NK cell attack, promoting bladder tumor metastasis

Core 2 β-1,6-N-acetylglucosaminyltransferase (C2GnT) forms an N-acetylglucosamine branch in O-glycans (core 2 O-glycans) of cell surface glycoproteins. C2GnT-expressing bladder tumors acquire highly metastatic phenotypes by surviving longer in host blood circulation. However, the detailed mechanisms...

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Huvudupphovsmän: SUZUKI, YUICHIRO, SUTOH, MIHOKO, HATAKEYAMA, SHINGO, MORI, KAZUYUKI, YAMAMOTO, HAYATO, KOIE, TAKUYA, SAITOH, HISAO, YAMAYA, KANEMITSU, FUNYU, TOMIHISA, HABUCHI, TOMONORI, ARAI, YOICHI, FUKUDA, MINORU, OHYAMA, CHIKARA, TSUBOI, SHIGERU
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396290/
https://ncbi.nlm.nih.gov/pubmed/22446589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2012.1411
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