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High molecular weight hyaluronan decreases oxidative DNA damage induced by EDTA in human corneal epithelial cells

PURPOSE: To investigate the toxic effects of ethylenediaminetetraacetic acid disodium salt (EDTA), a corneal penetration enhancer in topical ophthalmic formulations, on DNA in human corneal epithelial cells (HCEs), and to investigate whether the effect induced by EDTA can be inhibited by high molecu...

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Detalhes bibliográficos
Main Authors: Ye, J, Wu, H, Wu, Y, Wang, C, Zhang, H, Shi, X, Yang, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396180/
https://ncbi.nlm.nih.gov/pubmed/22595911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/eye.2012.89
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