Safety, tolerability, and bioavailability of topical SAR 1118, a novel antagonist of lymphocyte function-associated antigen-1: a phase 1b study

PURPOSE: A growing body of evidence points to a role for inflammation mediated by lymphocyte function-associated antigen-1 (LFA-1) and its ligand intercellular adhesion molecule-1 in the pathogenesis of diabetic macular oedema. This phase 1b clinical trial assessed the safety, tolerability, and phar...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Paskowitz, D M, Nguyen, Q D, Gehlbach, P, Handa, J T, Solomon, S, Stark, W, Shaikh, O, Semba, C, Gadek, T R, Do, D V
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
Schlagworte:
Clinical Study
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396168/
https://ncbi.nlm.nih.gov/pubmed/22538219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/eye.2012.68
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