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Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis

To achieve mitosis and cytokinesis, microtubules must assemble into distinct structures at different stages of cell division—mitotic spindles to segregate the chromosomes before anaphase and midzones to keep sister genomes apart and guide the cleavage furrow after anaphase. This temporal regulation...

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Main Authors: Hu, Chi-Kuo, Özlü, Nurhan, Coughlin, Margaret, Steen, Judith J., Mitchison, Timothy J.
格式: Artigo
語言:Inglês
出版: The American Society for Cell Biology 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395659/
https://ncbi.nlm.nih.gov/pubmed/22621898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-01-0058
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