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A secretagogue-siRNA conjugate confers resistance to cytotoxicity in a cell model of Sjögren's syndrome

OBJECTIVE: Sjögren's syndrome (SjS) is characterized by xerophthalmia and xerostomia resulting from loss of secretory function due to immune cell infiltration in lacrimal and salivary glands. Current SjS therapeutic strategies employ secretagogues to induce secretion via muscarinic receptor sti...

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Auteurs principaux: Pauley, Kaleb M., Gauna, Adrienne E., Grichtchenko, Irina I., Chan, Edward K.L., Cha, Seunghee
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395589/
https://ncbi.nlm.nih.gov/pubmed/21567383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.30450
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