Control and Augmentation of Long-Term Plasmid Transgene Expression In Vivo in Murine Muscle Tissue and Ex Vivo in Patient Mesenchymal Tissue

Purpose. In vivo gene therapy directed at tissues of mesenchymal origin could potentially augment healing. We aimed to assess the duration and magnitude of transene expression in vivo in mice and ex vivo in human tissues. Methods. Using bioluminescence imaging, plasmid and adenoviral vector-based tr...

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Detalhes bibliográficos
Main Authors: Morrissey, David, van Pijkeren, Jan P., Rajendran, Simon, Collins, Sara A., Casey, Garrett, O'Sullivan, Gerald C., Tangney, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395381/
https://ncbi.nlm.nih.gov/pubmed/22811595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/379845
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