The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress

The p57(Kip2) cyclin-dependent kinase inhibitor (CDKi) has been implicated in embryogenesis, stem-cell senescence and pathologies, but little is known of its role in cell cycle control. Here, we show that p57(Kip2) is targeted by the p38 stress-activated protein kinase (SAPK). Phosphorylation of p57...

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Autores principales: Joaquin, Manel, Gubern, Albert, González-Nuñez, Daniel, Josué Ruiz, E, Ferreiro, Isabel, de Nadal, Eulalia, Nebreda, Angel R, Posas, Francesc
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395087/
https://ncbi.nlm.nih.gov/pubmed/22569127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.122
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