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Limitations of the Human Reference Genome for Personalized Genomics

Data from the 1000 genomes project (1KGP) and Complete Genomics (CG) have dramatically increased the numbers of known genetic variants and challenge several assumptions about the reference genome and its uses in both clinical and research settings. Specifically, 34% of published array-based GWAS stu...

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Sonraí Bibleagrafaíochta
Main Authors: Rosenfeld, Jeffrey A., Mason, Christopher E., Smith, Todd M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394790/
https://ncbi.nlm.nih.gov/pubmed/22811759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040294
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