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Morphine-induced mu opioid receptor trafficking enhances reward yet prevents compulsive drug use
Morphine, heroin and other commonly abused opioids induce little mu opioid receptor (MOR) trafficking compared to endogenous opioids. We utilized knock-in mice expressing a mutant recycling MOR (RMOR) that desensitizes and is internalized in response to morphine to show that facilitating MOR traffic...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
WILEY-VCH Verlag
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3394511/ https://ncbi.nlm.nih.gov/pubmed/21656686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100144 |
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