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Should nucleotide sequence analyzing computer algorithms always extend homologies by extending homologies?

Most computer algorithms used for comparing or aligning nucleotide sequences rely on the premise that the best way to extend a homology between the two sequences is to select a match rather than a mismatch. We have tested this assumption and found that it is not always valid.

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Burnett, L, Basten, A, Hensley, W J
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 1986
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC339426/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3003678/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/14.1.425
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