Pilot study of rosiglitazone as an in vivo probe of paclitaxel exposure

AIMS: To evaluate the use of rosiglitazone and the erythromycin breath test (ERMBT), as probes of CYP2C8 and CYP3A4, respectively, to explain inter-individual variability in paclitaxel exposure. METHODS: The concentration of rosiglitazone at 3 h and ERMBT results were included in a regression model...

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Autors principals: Hertz, Daniel L, Walko, Christine M, Bridges, Arlene S, Hull, J Heyward, Herendeen, Jill, Rollins, Kristan, Watkins, Paul B, Dees, E Claire
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2012
Matèries:
Short Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394145/
https://ncbi.nlm.nih.gov/pubmed/22680343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04165.x
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