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Biophysical Mechanism of T Cell Receptor Triggering in a Reconstituted System

A T cell-mediated immune response is initiated by the T cell receptor (TCR) interacting with peptide-bound MHC (pMHC) on an infected cell. The mechanism by which this interaction triggers intracellular phosphorylation of the TCR, which lacks a kinase domain, remains poorly understood. Here, we have...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: James, John R., Vale, Ronald D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393772/
https://ncbi.nlm.nih.gov/pubmed/22763440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11220
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