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Biophysical Mechanism of T Cell Receptor Triggering in a Reconstituted System
A T cell-mediated immune response is initiated by the T cell receptor (TCR) interacting with peptide-bound MHC (pMHC) on an infected cell. The mechanism by which this interaction triggers intracellular phosphorylation of the TCR, which lacks a kinase domain, remains poorly understood. Here, we have...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3393772/ https://ncbi.nlm.nih.gov/pubmed/22763440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11220 |
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