Intranasal Immunization with a Formalin-Inactivated Human Influenza A Virus Whole-Virion Vaccine Alone and Intranasal Immunization with a Split-Virion Vaccine with Mucosal Adjuvants Show Similar Levels of Cross-Protection

The antigenicity of seasonal human influenza virus changes continuously; thus, a cross-protective influenza vaccine design needs to be established. Intranasal immunization with an influenza split-virion (SV) vaccine and a mucosal adjuvant induces cross-protection; however, no mucosal adjuvant has be...

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Autores principales: Okamoto, Shigefumi, Matsuoka, Sumiko, Takenaka, Nobuyuki, Haredy, Ahmad M., Tanimoto, Takeshi, Gomi, Yasuyuki, Ishikawa, Toyokazu, Akagi, Takami, Akashi, Mitsuru, Okuno, Yoshinobu, Mori, Yasuko, Yamanishi, Koichi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2012
Materias:
Vaccines
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393367/
https://ncbi.nlm.nih.gov/pubmed/22552600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00016-12
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